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Citalopram half life





Celexa (Citalopram Hydrobromide) Drug Information Clinical

01/09/2015
02:51 | Author: Nick Jenkins

Clonazepam half life
Celexa (Citalopram Hydrobromide) Drug Information Clinical

Biotransformation of citalopram is mainly hepatic, with a mean terminal half-life of about 35 hours. With once daily dosing, steady state plasma concentrations.

Read the Some Antidepressants May Raise Stroke Risk article »

Age - Citalopram pharmacokinetics in subjects ≥ 60 years of age were compared to younger subjects in two normal volunteer studies. In a single-dose study, citalopram AUC and half-life were increased in the subjects ≥ 60 years old by 30% and 50%, respectively, whereas in a multiple-dose study they were increased by 23% and 30%, respectively. 20 mg/day is the maximum recommended dose for patients who are greater than 60 years of age (see WARNINGS and DOSAGE AND ADMINISTRATION ), due to the risk of QT prolongation.

CYP2D6 poor metabolizers - Citalopram steady state levels were not significantly different in poor metabolizers and extensive metabolizers of CYP2D6.

Citalopram is metabolized to demethylcitalopram (DCT), didemethylcitalopram (DDCT), citalopram-N-oxide, and a deaminated propionic acid derivative.

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Citalopram - Wikipedia, the free encyclopedia

01/09/2015
10:38 | Author: Emma Coleman

Clonazepam half life
Citalopram - Wikipedia, the free encyclopedia

Some doctors choose to switch a patient to Prozac (Fluoxetine) when discontinuing Citalopram as Fluoxetine has a much longer half-life (i.e. stays in the body.

Tryptophan and 5-HTP are precursors to serotonin and can cause a rise in serotonin. When taken with an SSRI, such as citalopram, this can lead to levels of serotonin that can be lethal. This may also be the case when SSRI's are taken with SRA's ( Serotonin Releasing Agents ) such as in the case of MDMA. It is possible that SSRIs could reduce the effects associated due an SRA, due to the fact that SSRIs stop the reuptake of Serotonin by blocking SERT. This would allow less Serotonin in and out of the transporters, thus decreasing the likelihood of neurotoxic effects.

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Celexa Citalopram Profile - SSRI Antidepressant - Bipolar Disorder

01/09/2015
08:07 | Author: Kayla Henderson

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Celexa Citalopram Profile - SSRI Antidepressant - Bipolar Disorder

Celexa - generic citalopram - is a medication used to treat depression. Finally, the half-life of Celexa is about 1.5 days, which means that if you stop taking it.

Disclaimer: This is not intended to be all-inclusive or to replace information provided by your doctor or with the prescription from the manufacturer.

Updated June 02, 2014.

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Celexa - FDA prescribing information, side effects and uses

01/09/2015
06:44 | Author: Lauren Ross

Clonazepam half life
Celexa - FDA prescribing information, side effects and uses

Biotransformation of citalopram is mainly hepatic, with a mean terminal half-life of about 35 hours. With once daily dosing, steady state plasma concentrations.

A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least five of the following nine symptoms: depressed mood, loss of interest in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt or suicidal ideation.

The single- and multiple-dose pharmacokinetics of citalopram are linear and dose-proportional in a dose range of 10-60 mg/day.

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Citalopram 20mg Tablets - Summary of Product Characteristics (SPC)

01/09/2015
04:15 | Author: Kayla Henderson

Clonazepam half life
Citalopram 20mg Tablets - Summary of Product Characteristics (SPC)

Each film-coated tablet contains 20 mg citalopram (as citalopram.. The half-life of citalopram is about twice as long and steady state.

In patients with diabetes, treatment with an SSRI may alter glycaemic control, possibly due to improvement of depressive symptoms. Insulin and or oral hypoglycaemic dosage may need to be adjusted. Serotonin syndrome.

A pharmacokinetic / pharmacodynamic interaction study with concomitantly administered citalopram (20 mg daily) and selegiline (10 mg daily) (a selective MAO-B inhibitor) demonstrated no clinically relevant interactions. The concomitant use of citalopram and selegiline (in doses above 10 mg daily) is not recommended.

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