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Citicoline mechanism of action





Citicoline - Wikipedia, the free encyclopedia

7/23/2014
05:30 | Author: David Perry

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Citicoline - Wikipedia, the free encyclopedia

2 Mechanism of action. 2.1 Neuroprotective effects; 2.2 Neuronal membrane; 2.3 Cell signalling; 2.4 Blood flow; 2.5 Inflammation and stress; 2.6 Glutamate.

The brain prefers to use choline to synthesize acetylcholine. This limits the amount of choline available to synthesize phosphatidylcholine. When the availability of choline is low or the need for acetylcholine increases, phospholipids containing choline can be catabolized from neuronal membranes. These phospholipids include sphingomyelin and phosphatidylcholine. Supplementation with citicoline can increase the amount of choline available for acetylcholine synthesis and aid in rebuilding membrane phospholipid stores after depletion.

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Citicoline (CDP-choline) mechanisms of action and effects in

5/22/2014
03:20 | Author: David Perry

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Citicoline (CDP-choline) mechanisms of action and effects in

Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. D'Orlando KJ, Sandage BW Jr. Citicoline is approved in Europe and Japan.

Citicoline is approved in Europe and Japan for use in stroke, head trauma and other neurological disorders. It is presently being evaluated in phase II/III stroke trials in the United States. Exogenous administration of CDP-choline provides both choline and cytidine which access the brain and serve as substrates for the synthesis of phosphatidylcholine, a primary neuronal membrane component; the choline also enhances brain acetylcholine synthesis. Membrane repair and regeneration is necessary for recovery from stroke. Furthermore, citicoline may alleviate free fatty acid-induced toxicity which accompanies ischemic insult. Data from many pre-clinical and clinical trials support the hypothesis that citicoline may be a safe and effective treatment for stroke.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Citicoline Uses, Side Effects, Interactions and Warnings - WebMD

3/21/2014
01:30 | Author: David Perry

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Citicoline Uses, Side Effects, Interactions and Warnings - WebMD

Find patient medical information for citicoline on WebMD including its uses, effectiveness, side effects and safety, interactions, user ratings and products that.

Di, Trapani G. and Fioravanti, M. [Citicoline in the treatment of cognitive and behavioral disorders in pathologic senile decline]. Clin.Ter. ;137(6):403-413. View abstract.

Clark, W. M., Wechsler, L. R., Sabounjian, L. A., and Schwiderski, U. E. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology. ;57(9):. View abstract.

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Fridman, E. A., Ottaviano, F., Fiol, M., Javelier, A., Perea, J. E., and Ameriso, S. F.

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Citicoline neuroprotective mechanisms in cerebral ischemia

11/30/2014
09:40 | Author: David Perry

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Citicoline neuroprotective mechanisms in cerebral ischemia

Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials. The therapeutic action of.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Cytidine-5'-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain. Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials. The therapeutic action of citicoline is thought to be caused by stimulation of PtdCho synthesis in the injured brain, although the experimental evidence for this is limited. This review attempts to shed some light on the properties of citicoline that are responsible for its effectiveness. Our studies in transient cerebral ischemia suggest that citicoline might enhance reconstruction (synthesis) of PtdCho and sphingomyelin, but could act by inhibiting the destructive processes (activation of phospholipases). Citicoline neuroprotection may include: (i) preserving cardiolipin (an exclusive inner mitochondrial membrane component) and sphingomyelin; (ii) preserving the arachidonic acid content of PtdCho and phosphatidylethanolamine; (iii) partially restoring PtdCho levels; (iv) stimulating glutathione synthesis and glutathione reductase activity; (v) attenuating lipid peroxidation; and (vi) restoring Na(+)/K(+)-ATPase activity. These observed effects of citicoline could be explained by the attenuation of phospholipase A(2) activation. Based on these findings, a singular unifying mechanism has been hypothesized. Citicoline also provides choline for synthesis of neurotransmitter acetylcholine, stimulation of tyrosine hydroxylase activity and dopamine release.

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Citicoline Indication and Nursing Management Nursing Crib

9/29/2014
07:10 | Author: David Perry

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Citicoline Indication and Nursing Management Nursing Crib

Classification: Neurotonics, Nootropics. Mechanism of Action. Citicoline seems to increase a brain chemical called phosphatidylcholine.

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