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Eutroxsig Side Effects in Detail

Openmedi.orgEutroxsig side effects


8/15/2014
12:26 | Author: Emma Coleman

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Eutroxsig Side Effects in Detail

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Cardiac function was evaluated in twenty patients requiring TSH suppression for either thyroid goiter or following thyroidectomy and radioactive iodine therapy for thyroid cancer and in twenty age- and sex-matched controls. TSH suppression was associated with an increased incidence of premature ventricular beats, an increased left ventricular mass index, and enhanced left ventricular systolic function. The clinical significance of these changes remains to be determined. A 38-year-old female experienced with severe hypothyroidism experienced myxedema coma and cardiac ischemia coincident with levothyroxine (the active ingredient contained in Eutroxsig) therapy. After 3 months of levothyroxine therapy (initial dose: 12.5 mcg/d; maintenance dose: 125 mcg/d), all abnormal laboratory values associated with hypothyroidism returned to normal. However, three weeks after initiating treatment, the patient reported intermittent chest pains during the course of treatment, and a coronary artery angiogram revealed diffuse stenosis of all 3 branches. She underwent coronary artery bypass grafting, with subsequent improvement in coronary perfusion.

Applies to levothyroxine: oral capsule liquid filled, oral tablet Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by levothyroxine (the active ingredient contained in Eutroxsig). In the event that any of these side effects do occur, they may require medical attention.

Musculoskeletal side effects have included an increase risk of osteoporosis. However, data from long-term studies are conflicting.

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Generic Name: levothyroxine.

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You should check with your doctor immediay if any of these side effects occur when taking levothyroxine:

Nervous system side effects have rarely included seizures during initiation of therapy.

CSA Schedule N Not a controlled drug.

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Availability Rx Prescription only.

Note: This page contains information about the side effects of levothyroxine. Some of the dosage forms included on this document may not apply to the brand name Eutroxsig.

Data sources include Micromedex (updated Sep 26th, 2014), Cerner Multum (updated Oct 16th, 2014), Wolters Kluwer (updated Oct 9th, 2014) and others. To view content sources and attributions, refer to our editorial policy.

Dermatologic side effects including transient dermatologic effect and hair loss have been reported during the initial months of therapy.

A study evaluated the effect of long-term thyroid hormone therapy on bone mineral density in 196 women (mean age, 74.4 years) compared to a control group comprised of 795 women (mean age, 72.1 years). The mean daily thyroxine dose was 1.99 mcg/kg (range, 0.3 to 6.6 mcg/kg) with a mean duration of therapy of 20.4 years (range, less than 1 to 68 years). Women taking daily doses of 1.6 mcg/kg or more had significantly lower bone mineral density levels at the ultradistal radius, midshaft radius, hip, and lumbar spine compared to controls. However, estrogen use appeared to negate the adverse effects of thyroid hormone on bone mineral density. Higher rates of femur fractures have been found in males (p=0.008) prescribed long-term thyroid hormone therapy as compared to controls in a case-control analysis of 23,183 patients, from the United Kingdom General Practice Research Database, prescribed thyroid hormone.

Endocrine side effects have included changes in symptom presentation for diabetes and adrenal cortical insufficiency.

Cardiovascular side effects have included symptoms of palpitations, hypertension, tachycardia, and angina which may be exacerbated in patients with underlying cardiovascular disorders. Ischemic heart disease and significant effects on cardiac function including an increased incidence of premature ventricular beats, an increased left ventricular mass index, and enhanced left ventricular systolic function have been reported in clinical trials.

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Levothyroxine is usually well tolerated. Side effects associated with levothyroxine (the active ingredient contained in Eutroxsig) therapy typically resulted from therapeutic overdosage and included the signs and symptoms of hyperthyroidism. Weight loss, increased appetite, insomnia, anxiety, heat intolerance, diarrhea or increase in bowel frequency, palpitations, hypertension, tachycardia, angina, and menstrual irregularities may be reported. Given the long half-life of levothyroxine, such effects may not be present for several weeks after therapy initiation or dosage increases.

Pregnancy Category A Studies show no risk.

If any of the following symptoms of overdose occur while taking levothyroxine, get emergency help immediay:

For Healthcare Professionals Applies to levothyroxine: compounding powder, injectable powder for injection, intravenous powder for injection, oral capsule, oral tablet.

Not all side effects for Eutroxsig may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Some of the side effects that can occur with levothyroxine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to l you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:


Eutroxsig side effects