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Lactic acidosis





Lactic acidosis - Wikipedia, the free encyclopedia

9/21/2014
07:10 | Author: David Perry

Lactic acidosis
Lactic acidosis - Wikipedia, the free encyclopedia

Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood (acidosis) accompanied by the buildup of lactate, especially.

The excess hydrogen cations produced during lactic acidosis are widely believed to actually derive from production of lactic acid. This is incorrect, as cells do not produce lactic acid; pyruvate is converted directly into lactate, the anionic form of lactic acid. When excess intracellular lactate is released into the blood, maintenance of electroneutrality of the blood requires that a cation be released into the blood, as well. This can reduce blood pH. Glycolysis coupled with lactate production is neutral in the sense that it does not produce excess hydrogen cations, however, pyruvate production does produce them.

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Lactic acidosis MedlinePlus Medical Encyclopedia

7/20/2014
05:20 | Author: David Perry

Lactic acidosis
Lactic acidosis MedlinePlus Medical Encyclopedia

Lactic acidosis is when lactic acid builds ups in the bloodstream faster than it can be removed. Lactic acid is produced when oxygen levels in the body drop.

Lactic acidosis is when lactic acid builds ups in the bloodstream faster than it can be removed. Lactic acid is produced when oxygen levels in the body drop.

Collings JL. Acid-base disorders. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 7th ed. Philadelphia, Pa:Mosby Elsevier;2009:chap 122.

The main treatment for lactic acidosis is to correct the medical problem that causes the condition.

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A.D.A.M., Inc.

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Lactic Acidosis - Symptoms, Causes, Treatments - HealthGrades

5/19/2014
03:30 | Author: David Perry

Lactic acidosis
Lactic Acidosis - Symptoms, Causes, Treatments - HealthGrades

Lactic Acidosis Information Including Symptoms, Diagnosis, Treatment, Causes, Videos, Forums, and local community support. Find answers to.

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Lactic acidosis is a type of acidosis that occurs when the blood becomes too acidic due to the presence of excess lactic acid in the body. Blood pH is tightly controlled because even slight changes in your pH can have severe effects on many organs. Normally, your blood is slightly basic, or alkaline. Acidosis occurs when the blood becomes more acidic than normal.

Seek prompt medical care if you are being treated for lactic acidosis but mild symptoms recur or are persistent.

Medical conditions that can cause lactic acidosis include severe infections, kidney or liver disease, respiratory disease, heart disease, seizures, shock, cancer, severe anemia, and diabetes.

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Metformin and Fatal Lactic Acidosis - Medsafe

3/18/2014
01:20 | Author: David Perry

Lactic acidosis
Metformin and Fatal Lactic Acidosis - Medsafe

Metformin is a useful anti-hyperglycaemic agent but significant mortality is associated with drug-induced lactic acidosis. Significant renal and hepatic disease.

Lactic acidosis appears to result from biguanide interference causing an increase in production and decrease in clearance of lactate leading to higher cellular lactate levels. Intracellular redox potential then shifts from aerobic to anaerobic metabolism. A decrease in pyruvate carboxylase activity, the rate limiting enzyme in the formation of glucose from lactate, can also decrease hepatic metabolism of lactate.

Significant mortality (reported as high as 50% 3 ) is associated with biguanide-induced lactic acidosis and attention should be focused on prevention through awareness of the risk factors.

Examples of metformin-induced lactic acidosis cases reported to CARM include:

Metformin is also contraindicated in chronic hepatic disease because of the increased risk of metformin-associated lactic acidosis.

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Exercise-Related Lactic Acidosis Symptoms, Treatment, Causes

1/17/2014
01:10 | Author: David Perry

Lactic acidosis
Exercise-Related Lactic Acidosis Symptoms, Treatment, Causes

Lactic acidosis occurs when lactic acid accumulates in the bloodstream. Learn more from WebMD about the symptoms, causes, and treatments.

NIH: "Side Effects of HIV Medications: HIV and Lactic Acidosis.".

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Begin any exercise routine gradually. Pace yourself. Don't go from being a couch potato to trying to run a marathon in a week. Start with an aerobic exercise like running or fast walking. You can build up your pace and distance slowly. Increase the amount of exercise each week so your body builds up a tolerance. This will increase your "lactate threshold," making it less likely you'll get lactic acidosis.

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