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Lercanidipine a review of its use in hypertension

10/10/2014
01:09 | Author: Brandon Powell

Lercanidipine side effects nhs
Lercanidipine a review of its use in hypertension

Lercanidipine is a vasoselective dihydropyridine calcium antagonist which BP yielded a trough/peak ratio of >0.8 for both lercanidipine dosages in 1 study.

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Lercanidipine is an effective and well tolerated once daily antihypertensive agent in patients with mild to moderate hypertension. In addition, the drug may reduce BP when used as monotherapy in patients with severe hypertension or when used adjunctively in patients with resistant hypertension. Importantly, lercanidipine appears to be at least as effective and well tolerated as other commonly used antihypertensive agents. The drug therefore represents a useful therapeutic option in the management of patients with hypertension and will be particularly useful in patients not responding to, or intolerant of, antihypertensive agents from other drug classes.

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Tolerability of high doses of lercanidipine versus high doses of other

8/9/2014
03:22 | Author: David Perry

Lercanidipine side effects forum
Tolerability of high doses of lercanidipine versus high doses of other

The TOLERANCE study was aimed to compare the tolerability of high doses of lercanidipine (20 mg) with that of other frequently used dihydropyridines.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

The TOLERANCE study was aimed to compare the tolerability of high doses of lercanidipine (20 mg) with that of other frequently used dihydropyridines (amlodipine 10 mg/nifedipine GITS 60 mg) in the treatment of essential hypertension in daily clinical practice. It was an observational, transversal, multicentre study performed in a Primary Care Setting. A total of 650 evaluable patients with essential hypertension and age > or = 18 years were included. They had been treated with high doses of lercanidipine (n= 446) or amlodipine/nifedipine GITS (n= 204) during at least 1 month and previously with low doses (10 mg, 5 mg, and 30 mg, respectively) of the same drugs. The main objective was to compare the rates of vasodilation-related adverse events between both groups. Rates of signs and symptoms related to vasodilation were significantly higher (P < 0.001) in the amlodipine/nifedipine GITS group (76.8%, CI 95%) than in lercanidipine group (60.8%, ). Blood pressure control (< 140/90 mmHg or <130/80 for diabetics) and type of concomitant antihypertensive medications were similar in both groups. Treatment compliance was good (around 93%) and fairly comparable in both groups. Most adverse events with lercanidipine were mild (74.5% vs. 64% in amlodipine/nifedipine GITS group, P= 0.035) whereas severe adverse event rates did not differ significantly between groups (2.8% vs. 3.6%). In conclusion, treatment with lercanidipine at high doses is associated with a lower rate of adverse events related to vasodilation compared to high doses of amlodipine or nifedipine GITS in clinical practice.

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Lercanidipine in Hypertension

6/8/2014
05:33 | Author: Nick Jenkins

Lercanidipine side effects forum
Lercanidipine in Hypertension

It produces even and sustained blood pressure lowering with once-daily dosing. It has equivalent antihypertensive efficacy to many other agents and is effective.

Calcium antagonists are a heterogeneous group of established antihypertensive agents that includes the phenylalkylamine, verapamil, the benzothiazepine, diltiazem, and the dihydropyridines (DHPs). The landmark series of prospective trials comparing calcium antagonists with other antihypertensive medications showed that, as a class, calcium antagonists produce similar effects to diuretics, β-blockers, and ACE inhibitors on cardiovascular mortality and combined morbidity, and that they reduce stroke in elderly hypertensive patients with isolated systolic hypertension (ISH) ( Hansson et al 1999, 2000 ; Brown et al 2000 ; ALLHAT Officers and Coordinators 2002 ).

Hypertension is a major contributor to global disease burden, occurring as an insidious accompaniment to aging populations ( Kostis 2003 ; WHO 2003 ).

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Lercanidipine Full Prescribing Information, Dosage Side Effects

4/7/2014
07:24 | Author: Emma Coleman

Lercanidipine side effects forum
Lercanidipine Full Prescribing Information, Dosage Side Effects

Lercanidipine: . lercanidipine. Renal impairment: Dosage may need to be reduced in mild to moderate renal impairment. Avoid in patients with CrCl <12 ml/min.

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What are appropriate doses to use when switching hypertensive

2/6/2014
09:05 | Author: Kayla Henderson

Lercanidipine drug
What are appropriate doses to use when switching hypertensive

This Q&A addresses the issue of appropriate doses to use if considering transferring hypertensive patients from lercanidipine or lacidipine to amlodipine.

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