Anemia: Sulfasalazine may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count ( anemia) such as shortness of breath, feeling unusually tired or pale skin, contact your doctor as soon as possible.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
The dose of sulfasalazine varies widely according to the condition being treated and the needs of the person. The dose is usually started at a low dose and increased to the dose that is most effective. Side effects are more likely to occur with total daily doses of 4 g (4,000 mg) daily or more. Doses of sulfasalazine should be taken at regular and even intervals over the 24 hour daily period. If you are taking sulfasalazine for an intestinal inflammatory disease, the night-time dose interval should not be longer than eight hours. Doses for children are calculated on the basis of body weight.
Asthma: Sulfasalazine can cause breathing difficulty to increase for people with asthma. If you have asthma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
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While taking sulfasalazine, drink an adequate amount of fluids to minimize the risk of crystals in the urine and the forming of kidney stones.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
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Tablets Each yellow-orange, round, convex tablet, engraved with "KPh" on one side with "101" and a score on the other side, contains sulfasalazine 500 mg. Nonmedicinal ingredients: silicon dioxide, starch, and magnesium stearate. This medication does not contain tartrazine.
Children: This medication is not recommended for children with juvenile rheumatoid arthritis.
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Stop taking the medication and seek immediate medical attention if any of the following occur: signs of interstitial lung disease (e.g., shortness of breath or difficulty breathing) signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat) signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking sulfasalazine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Check with your doctor as soon as possible if any of the following side effects occur:
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Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediay.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.
Glucose-6-phosphate dehydrogenase enzyme deficiency: People without the G6PD enzyme should discuss with their doctor how this medication may affect the dosing and effectiveness of this medication.
Do not take sulfasalazine if you:
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Do not give this medication to children under 2 years of age.
Bleeding: Sulfasalazine may cause a reduced number of plaets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.
Infection: Sulfasalazine can reduce the number of cells that fight infection in the body (white blood cells). l your doctor immediay if you notice more frequent signs of infections, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Sulfasalazine belongs to the class of medications called anti-inflammatories. It is used to treat inflammatory bowel disease such as ulcerative colitis, proctitis or distal ulcerative colitis, and Crohn's disease. It helps control symptoms by reducing chronic inflammation in the bowel. The enteric-coated tablets can be used to treat rheumatoid arthritis when treatment with other medications has not helped. It may take 1 to 2 months before you see any results.
Liver disease: Sulfasalazine may reduce liver function and can cause liver failure. If you have liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. You will probably need to have regular liver tests while taking this medication. People with severe liver disease or very poor liver function should not take sulfasalazine.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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There may be an interaction between sulfasalazine and any of the following:
Allergies: Some people who are allergic to furosemide, thiazide water pills, or carbonic anhydrase inhibitors also experience allergic reactions to this medication. Before you take sulfasalazine, inform your doctor about any previous adverse reactions you have had to medications, especially water pills or sulfonamide antibiotics. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing or swelling of the face and throat.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
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Staining: Sulfasalazine may produce an orange-yellow colour in the urine. Similar discoloration of the skin and yellow staining of soft contact lenses have occasionally been reported.
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
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EN-tabs Each yellow-orange, elliptical, convex, enteric-coated tablet, engraved with "KPh" on one side and "102" on the other side, contains sulfasalazine 500 mg. Nonmedicinal ingredients: beeswax, carnauba wax, cellulose acetate phthalate, glyceryl monostearate, polyethylene glycol, propylene glycol, and talc. This medication does not contain tartrazine.
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Fertility: Infertility has been observed for some men treated with sulfasalazine. Stopping the medication appears to reverse these effects.
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Medications other than those listed above may interact with this medication. l your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also l them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
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Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The uncoated tablets should be taken with a meal if possible. The enteric-coated tablets must not be chewed or crushed; they should be swallowed whole.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Tablets in stool: If you notice intact enteric-coated tablets in your stool, contact your doctor.
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A personal relationship means the relationship between an individual who sends a message and the individual to whom the message is sent, if those individuals have had direct, voluntary, two-way communications and it would be reasonable to conclude that they have a personal relationship, taking into consideration any relevant factors such as the sharing of interests, experiences, opinions and information evidenced in the communications, the frequency of communication, the length of time since the parties communicated or whether the parties have met in person.
Kidney disease: This medication can reduce kidney function. If you have kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. You will probably need to have regular tests while taking this medication to make sure that your kidneys are working properly. People who have severe kidney problems should not use this medication.