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Zoloft (Sertraline Hcl) Drug Information Clinical Pharmacology

01/09/2015
12:53 | Author: Kayla Henderson

Alprazolam half life
Zoloft (Sertraline Hcl) Drug Information Clinical Pharmacology

The average terminal elimination half-life of plasma sertraline is about 26 hours. Based on this pharmacokinetic parameter, steady-state sertraline plasma levels.

Analyses for age and gender effects on outcome did not suggest any differential responsiveness on the basis of age or sex.

Antidepressants are a class of drugs that reduce symptoms of depressive disorders by correcting chemical imbalances of neurotransmitters in the brain. Chemical imbalances may be respo".

As might be predicted from its primary site of metabolism, liver impairment can affect the elimination of sertraline. In patients with chronic mild liver impairment (N=10, 8 patients with Child-Pugh scores of 5-6 and 2 patients with Child-Pugh scores of 7-8) who received 50 mg sertraline per day maintained for 21 days, sertraline clearance was reduced, resulting in approximay 3-fold greater exposure compared to age-matched volunteers with no hepatic impairment (N=10).

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Zoloft (Sertraline Hcl) Drug Information Indications, Dosage and

01/09/2015
08:34 | Author: Emma Coleman

Alprazolam half life
Zoloft (Sertraline Hcl) Drug Information Indications, Dosage and

Learn about indications, dosage and how it is supplied for the drug Zoloft (Sertraline Hcl).

The efficacy of ZOLOFT in the treatment of PTSD was established in two 12-week placebo-controlled trials of adult outpatients whose diagnosis met criteria for the DSM-III-R category of PTSD (see Clinical Trials under CLINICAL PHARMACOLOGY ).

ZOLOFT should be administered once daily, either in the morning or evening.

Neonates exposed to ZOLOFT and other SSRIs or SNRIs, late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding (see PRECAUTIONS ).

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Sertraline - FDA prescribing information, side effects and uses

01/09/2015
06:01 | Author: Brandon Powell

Alprazolam half life
Sertraline - FDA prescribing information, side effects and uses

The average terminal elimination half-life of plasma Sertraline is about 26 hours. Based on this pharmacokinetic parameter, steady-state Sertraline plasma.

Study 2 was a 12-week fixed-dose study, including Sertraline doses of 50, 100, and 200 mg/day. Patients receiving Sertraline doses of 50 and 200 mg/day experienced mean reductions of approximay 6 points on the YBOCS total score which were significantly greater than the approximay 3 point reduction in placebo-treated patients.

Posttraumatic Stress Disorder (PTSD).

Sertraline is extensively metabolized and excretion of unchanged drug in urine is a minor route of elimination. In volunteers with mild to moderate (CLcr=30 to 60 mL/min), moderate to severe (CLcr=10 to 29 mL/min) or severe (receiving hemodialysis) renal impairment (N=10 each group), the pharmacokinetics and protein binding of 200 mg Sertraline per day maintained for 21 days were not altered compared to age-matched volunteers (N=12) with no renal impairment.

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Zoloft Dosage

01/09/2015
04:52 | Author: Emma Coleman

Alprazolam half life
Zoloft Dosage

Patients not responding to a 50 mg dose may benefit from dose increases up to a maximum of 200 mg/day. Given the 24 hour elimination half-life of ZOLOFT.

A major loss, such as the death of a family member, can trigger feelings of grief. But being clinically depressed is different. So, how can you l which is.

ZOLOFT treatment should be initiated with a dose of 25 mg once daily. After one week, the dose should be increased to 50 mg once daily.

Women with post-traumatic stress disorder seem more likely than others to develop type 2 diabetes, with severe PTSD almost doubling the risk, a new study.

Symptoms associated with discontinuation of ZOLOFT and other SSRIs and SNRIs, have been reported (see PRECAUTIONS ).

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Taking Zoloft dosing into my own hands. - Depression - MedHelp

01/09/2015
02:25 | Author: Kayla Henderson

Alprazolam half life
Taking Zoloft dosing into my own hands. - Depression - MedHelp

I have read that the half life of Zoloft is significantly smaller than that of the other A.D. meds, making me wonder if I need to continue to increase.

This patient support community is for discussions relating to depression, counseling, sleep problems, and nutrition.

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