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Retrospective Population Cohort Study on Hip Fracture Risk - Sleep

5/14/2014
12:53 | Author: Kayla Henderson

Sleep medicine zolpidem
Retrospective Population Cohort Study on Hip Fracture Risk - Sleep

Retrospective Population Cohort Study on Hip Fracture Risk Associated with Zolpidem Medication. http://dx.doi.org/10.5665/sleep.3566. Fang-Yu Lin, MSPH1,2;.

1Department of Public Health, China Medical University, Taichung, Taiwan; 2Department of Epidemiology, University of Texas School of Public Health, Houston, TX; 3Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan; 4Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan; 5Department of Pharmacy, China Medical University Hospital, Taichung, Taiwan.

Population-based retrospective cohort study using claims data of a universal insurance system.

Lin FY; Chen PC; Liao CH; Hsieh YW; Sung FC. Retrospective population cohort study on hip fracture risk associated with zolpidem medication. SLEEP 2014;37(4):673-679.

Fang-Yu Lin, MSPH1,2; Pei-Chun Chen, PhD, MSPH3; Chun Hui Liao, MD, MSPH4; Yow-Wen Hsieh, PhD5; Fung-Chang Sung, PhD, MPH1.

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We identified 6,978 patients newly prescribed for zolpidem in age 18 y and older, and 27,848 nonusers frequency matched with sex, age, and date visiting a clinic.

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Both cohorts were followed up to the end of 2008 to measure the hip fracture incidence and risk, which considered factors such as sex, age, occupation, days of drug use, and osteoporosis status. The zolpidem users had a 2.23-fold higher hip fracture incidence than nonusers (3.10 versus 1.39 per 1,000 person-y). The risk increased with age for both cohorts. The elderly users had a 21-fold higher incidence than the younger users, or twofold higher than the elderly nonusers. Among 33 patients (20.4%) with hip fracture occurring during presumed medication days, which was accountable for an incidence of 1,083.0 per 1,000 person-y. Those taking the medicine for 8 days or longer had a moderay higher fracture rate than those taking it for less days (6.02 versus 4.48 per 100 person-times) with a ratio of 1.34 (95% confidence interval 0.42-4.56). Subjects with blue collar occupations were at a higher fracture risk.

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You may access and print any article from SLEEP for your personal scholarly, research, and educational use. Please note, access to the article is from the computer on which the article was purchased only. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of APSS. Further, purchase does not permit the posting the article text on an online forum or website.

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The hip fracture risk of zolpidem users is higher than that of nonusers. Fracture prevention awareness should be disseminated to the users.

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Few studies have evaluated the hip fracture risk for zolpidem users. We assessed the risk for subjects taking zolpidem.

Non-subscribers have the opportunity to purchase access to individual articles for U.S. $8.00.

You may access and print any article from SLEEP for your personal scholarly, research, and educational use. Please note, access to the article is from the computer on which the article was purchased only. Purchase of the article does not permit distribution, electronic or otherwise, of the article without the written permission of APSS. Further, purchase does not permit the posting the article text on an online forum or website. http://dx.doi.org/10.5665/sleep.3566.

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