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Sodium valproate side effects in pregnancy





Sodium valproate special reminder on risk of neurodevelopmental

6/10/2014
05:49 | Author: Brandon Powell

Ambien overdose
Sodium valproate special reminder on risk of neurodevelopmental

These studies have highlighted that in some children the effects appear to Sodium valproate should not be used during pregnancy and in.

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In Safety information.

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The use of sodium valproate is associated with a greater risk of some types of these malformations (in particular neural tube defects) than with some other antiepileptic drugs. This risk is clearly reflected in the product information provided for patients and prescribers.

Advice for healthcare professionals: Further information.

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Article citation: Drug Safety Update volume 7 issue 4, November 2013: A2.

Sodium valproate (brand name Epilim) has been authorised since 1973 for the treatment of epilepsy.

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Should valproate be taken during pregnancy?

4/9/2014
07:58 | Author: David Perry

Zolpidem overdose treatment
Should valproate be taken during pregnancy?

At higher valproate doses, the mean rate of pregnancy with fetal AEDs other than valproate, and 172 had received valproate (always as the sodium salt) either The effect of valproate dosage in the first trimester of pregnancy on the rates of.

The association between higher valproate doses and increasing rates of pregnancies with fetal malformation might have been due to higher drug doses being needed to treat more difficult-to-control epilepsy, with this epilepsy being responsible for the higher malformation rates. Therefore, rates of pregnancies with fetal malformation were compared in valproate-treated pregnancies in which bilateral convulsive seizures had occurred in early pregnancy (3 of 23 such pregnancies yielding fetal malformations) and in pregnancies free from convulsive seizures in their early months (22 of 146 such pregnancies yielding fetal malformations).

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Epilim and pregnancy Epilepsy Action

12/18/2014
01:13 | Author: Nick Jenkins

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Epilim and pregnancy Epilepsy Action

“Mothers who took sodium valproate in pregnancy should be supported to. a terrible defect but we should be told about ALL side effects.

A support group for the people and families of those who were born with a fetal anti-convulsant syndrome.

Advice and Information team.

Nicole Crosby-McKenna, women’s officer at Epilepsy Action said: “The majority of women with epilepsy who are taking sodium valproate have healthy children. However, these findings highlight the importance of monitoring women with epilepsy throughout pregnancy.

We have recently developed a range of materials to ensure that obstetricians, midwives and GPs have access to up-to date expertise and advice about pregnancy and epilepsy.

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Sodium valproate in pregnancy - General Practice Notebook

10/17/2014
01:36 | Author: Emma Coleman

Ambien overdose
Sodium valproate in pregnancy - General Practice Notebook

Sodium valproate - associated with a 1.5% risk of neural tube defects. This may be attributed in part to its effect in reducing serum folate, itself thought to be.

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It is important for women to take folic acid prophylaxis preconceptually and during the first trimester. The dose of folic 5mg PO/day may be appropriate for women receiving established antiepileptic medication (1).

It is important to take specialist advice as to the management of epilepsy in women of childbearing potential.

Drugs for which there is good data include: Notes: Reference: Links: conditions.

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BBC News - Pregnant women 39unaware39 of epilepsy drug risks

8/16/2014
03:05 | Author: Kayla Henderson

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BBC News - Pregnant women 39unaware39 of epilepsy drug risks

Sodium valproate has long been known to increase babies' risk of the severe and extensive potential side effects that this drug can have.".

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As a GP with 24 years of experience I believe the warnings on this leaflet are inadequate. ”

Concern is growing that mothers-to-be are not aware enough of the dangers of an epilepsy drug known to cause severe abnormalities in foetuses.

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A spokesman for Sanofi said: " regularly review and make changes to core safety information in the light of emerging data that could have an impact on the safety profile of valproate.

Emma Murphy, who has epilepsy, has given birth to five children with health problems she believes were caused by sodium valproate.

"There is no specific mention of long term learning difficulties, of low verbal IQ or autistic spectrum disorders.

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The current leaflet provided with another brand of the drug, made by Wockhardt, clearly highlights risks to any unborn child including spina bifida, congenital abnormalities and delayed development.

The drug's manufacturers insist they have always warned of the dangers.

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But it presents risks if taken by expectant mothers, with an increased chance of physical deformities.

"Over 20% of those women hadn't received any information in connection with pregnancy."

"We found out that children exposed to sodium valproate were at a greater risk of inlectual delay, memory problems, language difficulties and behavioural problems."

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But GP and broadcaster Rosemary Leonard said: "As a GP with 24 years of experience I believe the warnings on this leaflet are inadequate.

A new study has found 12% of babies exposed to the drug in the womb could have mental disorders.

regularly review and make changes to core safety information in the light of emerging data that could have an impact on the safety profile of valproate”

Health experts say women with epilepsy who are pregnant should not stop their medication but consult their GP or epilepsy specialist.

"The increased risk of spina bifida is 20 times higher than in the background population.

Mrs Murphy feels she was never warned about the dangers by either her doctors or the drugs company.

See more on this on Inside Out on Monday 25 February on BBC1 at 19:30 GMT.

"As a mum you do have the guilt trip."

The new report concludes children born to mothers on sodium valproate are six times more likely to be diagnosed with disorders such as autism.

"The product information made available to doctors by Sanofi in relation to sodium valproate has at all times since the product was first marketed in the early 1970s contained a warning of its teratogenic potential."

Speaking for the first time, its author, neuropsychologist Professor Gus Baker, said: "We followed up 600 from birth to six years of age.

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Dr Peter Turnpenny, consultant clinical geneticist at Royal Devon and Exeter Hospital, said: "We know the risk of physical birth defect is certainly 10%

National guidelines insist all women of child-bearing age with epilepsy should be informed about the risks the drug may have on an unborn baby.

"I'm finding a lot of women are not being warned about the potential risks of valproate."

"It wasn't until I was through my fourth pregnancy that I found out about the effects of Epilim (sodium valproate).

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