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Sodium valproate side effects liver





Valproate - LiverTox - National Institutes of Health

12/22/2014
08:18 | Author: Emma Coleman

Sodium valproate 500mg side effects
Valproate - LiverTox - National Institutes of Health

Valproate sodium is also available in parenteral formulations. Valproate has multiple side effects and clinically significant drug interactions; common side effects.

Introduction Valproate or valproic acid is a branched chain organic acid that is used as therapy of epilepsy, bipolar disorders and migraine headaches and is a well known cause of several distinctive forms of acute and chronic liver injury. Background Valproate (val proe' ate) is a carboxylic acid derivative that appears to act by increasing brain levels of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the human brain. Valproate has been shown to be effective in several forms of seizures.

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Valproic acid - Wikipedia, the free encyclopedia

10/21/2014
06:24 | Author: Lauren Ross

Sodium valproate 500mg side effects
Valproic acid - Wikipedia, the free encyclopedia

The acid, salt, or a mixture of the two (valproate semisodium) are marketed under a Less common, yet serious side effects include liver damage, brittle bones.

Valproic acid ( VPA, valproate ), an acidic chemical compound, has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. VPA is a liquid at room temperature, but it can be reacted with a base such as sodium hydroxide to form the salt sodium valproate, which is a solid.

Note: See the GABA A receptor PAMs navbox for a full list of GABA A positive allosteric modulators.

Valproate inhibits CYP2C9, glucuronyl transferase, and epoxide hydrolase and is highly protein bound and hence may interact with drugs that are substrates for any of these enzymes or are highly protein bound themselves.

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Sodium Valproate 500mg Gastro-resistant Tablets - Summary of

8/20/2014
04:14 | Author: Emma Coleman

Sodium valproate 500mg side effects
Sodium Valproate 500mg Gastro-resistant Tablets - Summary of

Liver dysfunction, including hepatic failure resulting in fatalities, has occurred in be helpful where there is poor control or side effects are suspected see section 5.2. Sodium valproate has no effect on serum lithium levels.

Sodium Valproate Zentiva 500mg Gastro-resistant Tablets 2. Qualitative and quantitative composition Sodium Valproate 500mg. 3. Pharmaceutical form Gastro-resistant Tablet. 4. Clinical particulars 4.1 Therapeutic indications In the treatment of generalised, partial or other epilepsy. 4.2 Posology and method of administration Sodium Valproate 500mg Gastro-resistant Tablets are for oral administration. Daily dosage requirements vary according to age and body weight. Sodium valproate tablets may be given twice daily.

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Effect of antiepileptic drugs on liver enzymes - ScienceDirect

6/19/2014
02:32 | Author: David Perry

Sodium valproate 500mg side effects
Effect of antiepileptic drugs on liver enzymes - ScienceDirect

the effect of carbamazepine, sodium valproate and phenytoin on serum liver (2004) reported that hepatotoxicity of phenytoin is an important side effect that.

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