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Synthesis of zolpidem





A simple and scalable synthesis of anti hypnotic agent, Zolpidem

11/23/2014
11:30 | Author: David Perry

Zolpidem heart
A simple and scalable synthesis of anti hypnotic agent, Zolpidem

A simple, efficient, scalable and cost effective synthesis of zolpidem is discussed. Zolpidem (1) is a short acting nonbenzodiazepine imidazopyridine hypnotic.

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Flow chemistry synthesis of zolpidem, alpidem - RSC Publishing

11/22/2014
09:00 | Author: David Perry

Zolpidem heart
Flow chemistry synthesis of zolpidem, alpidem - RSC Publishing

The flow of information between chemical and biological research can present a bottleneck in pharmaceutical research. Tools that bridge these disciplines and.

The flow of information between chemical and biological research can present a bottleneck in pharmaceutical research. Tools that bridge these disciplines and aid information exchange have therefore clear value. Over the last few years, both synthetic chemistry and biological screening have benefited from automation, and a seamless chemistry–biology interface is now possible. We report here on the use of flow processes to perform synthesis and biological evaluation in an integrated manner. As proof of concept, a flow synthesis of a series of imidazopyridines, including zolpidem and alpidem, was developed and connected to a Frontal Affinity Chromatography screening assay to investigate their interaction with Human Serum Albumin (HSA).

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Patent US20050054669 - Process for the synthesis of zolpidem

9/21/2014
07:50 | Author: David Perry

Zolpidem heart
Patent US20050054669 - Process for the synthesis of zolpidem

The present invention relates to processes for the preparation of zolpidem of Formula V as shown in the accompanying drawings or.

Zolpidem is disclosed in European Patent No. 50,563, which is an equivalent of U.S. Pat. No. 4,382,938. The pharmacological profile of this compound is characterized by a strong hypnotic effect, together with weak anticonvulsant and muscle-relaxant properties, selectivity for benzodiazepine receptors with the biochemical characteristics, and regional distribution of the benzodiazepine one subtype. While zolpidem is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex and shares some of the pharmacological properties of the benzodiazepines.

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An Efficient Synthesis of Zolpidem

7/20/2014
05:20 | Author: David Perry

Zolpidem heart
An Efficient Synthesis of Zolpidem

An Efficient Synthesis of Zolpidem. View full textDownload full text. Full access. DOI: 10.1080/ .2011.564558. Sachin S. Patila, Sachin.

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A simple and efficient synthesis of hypnotic agent, zolpidem and its

5/19/2014
03:10 | Author: David Perry

Zolpidem heart
A simple and efficient synthesis of hypnotic agent, zolpidem and its

A simple, efficient and scalable synthesis of hypnotic agent, zolpidem Yasareni Sumalatha, Tamma Ranga Reddy, Padi Pratap Reddy and Bollikonda.

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