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What is zolpidem hemitartrate





Selective potentiometric determination of zolpidem hemitartrate in

5/10/2014
01:52 | Author: Emma Coleman

Zolpidem drug testing
Selective potentiometric determination of zolpidem hemitartrate in

J AOAC Int. 2004 Nov-Dec;87(6):1309-18. Selective potentiometric determination of zolpidem hemitartrate in tablets and biological fluids by using polymeric.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

The construction and electrochemical response characteristics of 4 polymeric membrane sensors were investigated for potentiometric determination of zolpidem hemitartrate.

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Structural and thermal characterization of zolpidem hemitartrate

11/19/2014
09:36 | Author: Lauren Ross

Zolpidem drug schedule
Structural and thermal characterization of zolpidem hemitartrate

Structural and thermal characterization of zolpidem hemitartrate hemihydrate (Form E) and its decomposition products by laboratory X-ray powder diffraction.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

The crystal structure of zolpidem hemitartrate hemihydrate (I, Form E) has been solved from high-resolution laboratory powder diffraction data. It crystallizes in the orthorhombic P space group with a = 22.4664(6) A, b = 26.0420(7) A, and c = 7.4391(1) A. Protonation of zolpidem molecules could not be unambiguously determined. Thermal stability of Form E has been investigated by TG-DTA and in situ by temperature resolved X-ray powder diffraction. Water loss occurs between 50 degrees C <or= t <or= 100 degrees C while structure decomposition commences at approximay 120 degrees C yielding zolpidem tartrate (II) and pure zolpidem base (III) in approximay equimolar amounts. Crystal structures of II and III have been solved simultaneously from a single powder pattern of thermally decomposed I. Zolpidem tartrate crystallizes in the orthorhombic P space group with a = 19.9278(8) A, b = 15.1345(8) A, and c = 7.6246(2) A (at 140 degrees C). Zolpidem base crystallizes in the orthorhombic Pcab space group with a = 9.9296(4) A, b = 18.4412(9) A, and c = 18.6807(9) A (at 140 degrees C). In the reported crystal structures zolpidem molecules form stacks through pi-pi interaction or dipole-dipole interactions while tartrate moieties, if present, form hydrogen bonded chains. Water molecule in I forms a hydrogen bond to the imidazole nitrogen atom of the zolpidem molecule. Free space in the crystal structure of I could allow for the additional water molecules and thus a variable water content.

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2009 Wiley-Liss, Inc. and the American Pharmacists Association.

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Aging-driven decomposition in zolpidem hemitartrate hemihydrate

11/18/2014
07:04 | Author: Emma Coleman

Zolpidem drug screen
Aging-driven decomposition in zolpidem hemitartrate hemihydrate

The “aging-driven” decomposition of zolpidem hemitartrate hemihydrate (form A) has been followed by X-ray powder diffraction (XRPD), and.

Vega, D. R., Baggio, R., Roca, M. and Tombari, D. (2011), Aging-driven decomposition in zolpidem hemitartrate hemihydrate and the single-crystal structure of its decomposition products. J. Pharm. Sci., 100: 1377–1386. doi: 10.1002/jps.22358.

API Division, GADOR S.A., Calle 10, (1629) Parque Industrial Pilar, Buenos Aires, Argentina.

Article first published online: 1 OCT 2010 DOI: 10.1002/jps.22358.

Grupo Materia Condensada, GIyA, GAIyANN, CAC, Comisión Nacional de Energía Atómica, Av.

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Determination of zolpidem hemitartrate by quantitative HPTLC and LC

9/17/2014
05:48 | Author: David Perry

Zolpidem drug schedule
Determination of zolpidem hemitartrate by quantitative HPTLC and LC

Two methods are described for the determination of zolpidem hemitartrate in presence of its degradation product. The first method was a TLC-UV densitometric.

Volume 33, Issue 3, 15 October 2003, Pages 393–401 No articles found.

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Lipomed AG Available References - Zolpidem.hemitartrate

7/16/2014
03:20 | Author: David Perry

Zolpidem drug schedule
Lipomed AG Available References - Zolpidem.hemitartrate

Formula, C21H24N3O4. Product reference number, ZOL-919-TA. DEA No. 2783 CIV. ZOL-919-TA-1LM, 1.0 mg base/1 ml, solution in methanol. ZOL-919-TA-1.

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