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Low-Dose Sublingual Zolpidem Tartrate is Associated with Dose

8/12/2014
01:27 | Author: Nick Jenkins

Zolpidem duration
Low-Dose Sublingual Zolpidem Tartrate is Associated with Dose

Subjects were awakened 4 h after lights out, dosed with sublingual zolpidem tartrate However, the duration of action is also affected by dose, so studies are.

This randomized, double-blind, placebo-controlled, 3-way crossover study was conducted in 5 U.S. sleep laboratories. The study included 2 screening periods. The initial screening visit ensured that subjects met the general study inclusion criteria. At the second screening visit, subjects underwent 2 nights of PSG screening to confirm subject eligibility. Subjects' history of MOTN insomnia was confirmed by a 2-night single-blind placebo, PSG screening period, which included a scheduled 30-min MOTN awakening.

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Low-dose sublingual zolpidem tartrate is associated with dose

6/11/2014
03:14 | Author: Lauren Ross

Zolpidem duration
Low-dose sublingual zolpidem tartrate is associated with dose

Low-dose sublingual zolpidem tartrate is associated with dose-related improvement in sleep onset and duration in insomnia characterized by.

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To evaluate the efficacy and safety of low-dose, sublingual zolpidem tartrate when taken during a scheduled middle-of-the-night (MOTN) awakening in subjects with insomnia characterized by difficulty returning to sleep following MOTN awakenings.

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Each treatment period consisted of 2 consecutive nights of dosing separated by a washout of 5 to 12 days.

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Effect of zolpidem on sleep in insomniac patients - Springer

4/10/2014
05:21 | Author: Nick Jenkins

Zolpidem duration
Effect of zolpidem on sleep in insomniac patients - Springer

Zolpidem markedly increased the duration of Stage 2 sleep without affecting either slow wave sleep or REM sleep. Subjective evaluation of improvement in.

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Zolpidem markedly increased the duration of Stage 2 sleep without affecting either slow wave sleep or REM sleep. Subjective evaluation of improvement in sleep was well correlated with sleep laboratory findings. Zolpidem did not impair the immediate memory or psychomotor performance of patients on the morning after its administration. Side-effects during the period of drug administration included drowsiness, fatigue, headache, anxiety and irritability. They were mild or moderate and wore off soon after awakening.

The effect of zolpidem 10 mg p.o. on sleep in patients with persistent psychophysiological insomnia was assessed by polysomnographic recordings.

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An improvement in sleep with no rebound insomnia was observed during treatment for two weeks. Time awake after the onset of sleep was reduced after one week and increased after two weeks, whereas sleep latency remained reduced.

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