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Zolpidem effects on women





Effect of zolpidem on sleep in women with perimenopausal and

8/16/2014
01:25 | Author: Kayla Henderson

Zolpidem effects on women
Effect of zolpidem on sleep in women with perimenopausal and

Effect of zolpidem on sleep in women with perimenopausal and postmenopausal insomnia: a 4-week, randomized, multicenter, double-blind, placebo-controlled.

The purpose of this study was to assess the clinical efficacy and safety of zolpidem as a treatment for insomnia in perimenopausal and postmenopausal women.

Although most adults in the United States obtain less sleep than they need, women report more sleep deprivation throughout their lifetime than do men. The prevalence of self-reported sleep difficulty increases as women make the transition from the premenopausal to the postmenopausal period.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Zolpidem 10 mg/d was effective and well tolerated in the treatment of menopause-related insomnia in perimenopausal and postmenopausal women.

The study included 141 women (mean age +/- SD, 50.8 +/- 4.5 years; age range, 39-60 years). Increases in reported total sleep time were significantly greater in the zolpidem group than in the placebo group (P < 0.01) for each treatment week. Wake time after sleep onset and number of awakenings decreased significantly in the zolpidem group compared with the placebo group (P < 0.05). Each week, approximay twice as many patients in the zolpidem group as in the placebo group reported improved sleep (P < 0.001 for each week). The improvement in sleep-related difficulty with daytime functioning was significantly greater in the zolpidem group than in the placebo group (P < 0.05). The effects of zolpidem did not diminish with the duration of treatment.

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Effects of zolpidem and flunitrazepam on nocturnal sleep of women

6/15/2014
01:10 | Author: David Perry

Zolpidem effects on women
Effects of zolpidem and flunitrazepam on nocturnal sleep of women

Effects of zolpidem and flunitrazepam on nocturnal sleep of women subjectively complaining of insomnia. Declerck AC, Ruwe F, O'Hanlon JF, Vermeeren A.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

Eighteen non-pregnant woman complaining about insomnia were polysomnographically investigated for 3 nights with weekly intervals. They received placebo, 2 mg flunitrazepam or 10 mg zolpidem according to a cross-over double blind design. The patients were selected by general practitioners on the basis of subjective complaints. Zolpidem is a recently introduced short-acting imidazopyridine hypnotic, binding to a subunit of the benzodiazepine 1 receptor. Flunitrazepam is a well-known hypnotic, binding to both the benzodiazepine 1 and 2 receptor subtypes. Objective recording did not substantiate the subjective complaint of insomnia. Sleep patterns during placebo differed only little from that expected from age matched healthy persons. Both flunitrazepam and zolpidem significantly shortened sleep onset (5 min of continuous sleep beginning with NREM 1 sleep). The sleep composition following flunitrazepam was characterized by an increase in NREM 2, a prolongation of the time of REM sleep, a reduction of REM sleep and an increase in NREM 3-4 sleep during the first 2 h of sleep. The sleep composition following zolpidem resembled more than seen in persons without sleep complaints. However, as compared to placebo, there was a decrease of the time spent awake during sleep and an increase in NREM 3-4 during the first 2 of sleep.

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Effects Of Bedtime Administration Of Zolpidem On Circadian - Sleep

4/14/2014
03:15 | Author: Kayla Henderson

Zolpidem effects on women
Effects Of Bedtime Administration Of Zolpidem On Circadian - Sleep

VOLUME 18, ISSUE 06. Effects Of Bedtime Administration Of Zolpidem On Circadian And Sleep- Related Hormonal Profiles In Normal Women. Georges.

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Center for Biological Rhythms (CERB), Laboratory of Experimental Medicine and Laboratory of Clinical Chemistry, School of Medicine, Université Libre de Bruxelles, Bruxelles, Belgium and Department of Medicine, University of Chicago, Chicago, Illinois, U.S.A.

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