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Identification and Quantitation of Zolpidem in Biological Matrices

11/21/2014
05:08 | Author: David Perry

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Identification and Quantitation of Zolpidem in Biological Matrices

Zolpidem is a short-acting nonbenzodiazepine hypnotic used for the treatment of insomnia. It works quickly and has a short half-life of 2–3 h. Significant side.

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Zolpidem is a short-acting nonbenzodiazepine hypnotic used for the treatment of insomnia. It works quickly and has a short half-life of 2–3 h. Significant side effects are reported including dizziness, amnesia, and even hallucinations. In this method, zolpidem is extracted from blood or other biological fluids/tissues using solid phase extraction technology for analysis. The extract is then assayed using selected ion monitoring gas chromatography/mass spectrometry for absolute confirmation of the compound. The quantitation of this drug is made from standard curves constructed using selected ion monitoring and peak-area ratios of analyte vs. internal standard of quantifying ions.

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7/19/2014
01:36 | Author: Emma Coleman

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UHPLC-MSMS and UHPLC-HRMS identification of zolpidem and

5/18/2014
01:30 | Author: David Perry

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Zolpidem and zopiclone (Z-compounds) are non-benzodiazepine hypnotics of new generation that can be used in drug-facilitated sexual.

* Correspondence to: Sabina Strano Rossi, Institute of Legal Medicine, Catholic University of Sacred Heart, L.go F. Vito, 1, Rome, Italy.

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2013 John Wiley & Sons, Ltd. Issue.

Institute of Legal Medicine, Catholic University of Sacred Heart, Rome, Italy.

Strano Rossi, S., Anzillotti, L., Castrignanò, E., Frison, G., Zancanaro, F. and Chiarotti, M. (2014), UHPLC-MS/MS and UHPLC-HRMS identification of zolpidem and zopiclone main urinary metabolites and method development for their toxicological determination.

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