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Zolpidem in pregnancy





Increased risk of adverse pregnancy outcomes in women receiving

5/10/2014
06:59 | Author: Brandon Powell

Medication used for insomnia
Increased risk of adverse pregnancy outcomes in women receiving

Increased risk of adverse pregnancy outcomes in women receiving zolpidem during pregnancy. Wang LH, Lin HC, Lin CC, Chen YH, Lin HC.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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This nationwide population-based study was carried out in Taiwan with the aim of comparing the risk of adverse pregnancy outcomes in women who received zolpidem treatment for insomnia during pregnancy with that in women who did not. The adverse outcomes identified and assessed were delivery of low-birth-weight (LBW) infants, preterm deliveries, delivery of small-for-gestational-age (SGA) infants, delivery of infants with congenital anomalies, and cesarean delivery. The incidences of these were compared between the groups after adjusting for other characteristics of the mothers and infants. The study used the Taiwan National Health Insurance Research Dataset (NHIRD) and birth-certificate registry. In total, the data from 2,497 mothers who received zolpidem treatment during pregnancy and those from 12,485 randomly selected mothers who did not receive the drug were included in the analysis. The results show that the adjusted odds ratios (ORs) for adverse pregnancy outcomes--LBW infants, preterm deliveries, SGA infants, and cesarean delivery--were all higher in mothers who received zolpidem treatment during pregnancy, relative to the randomly selected controls (1.39 (95% confidence interval (CI) = 1.17-1.64), 1.49 (95% CI = 1.28-1.74), 1.34 (95% CI = 1.20-1.49), and 1.74 (95% CI = 1.59-1.90), respectively). In conclusion, the risk of adverse pregnancy outcomes was higher in women who received zolpidem during pregnancy than in those who did not.

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Zolpidem Addiction in a Pregnant Woman with a History of Second

11/18/2014
12:17 | Author: Nick Jenkins

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Zolpidem Addiction in a Pregnant Woman with a History of Second

Whether zolpidem crosses the placenta in humans is unknown. A 30-year-old Caucasian woman with a history of zolpidem abuse underwent.

Article first published online: 6 JAN 2012 DOI: 10.1592/phco.27.2.306.

*Jennifer P. Askew, Pharm.D., Outpatient Pharmacy Services, 2239 South 17th Street, Wilmington, NC 28402;

Whether zolpidem crosses the placenta in humans is unknown. A 30-year-old Caucasian woman with a history of zolpidem abuse underwent spontaneous vaginal delivery at 38 weeks' gestation. Total fetal exposure to zolpidem was unknown, but it was estimated to be at least 1000 mg over at least 1 month. Typical peak plasma concentrations after a single 5- and 10-mg dose of zolpidem are 29–113 ng/ml (mean 59 ng/ml) and 58–272 ng/ml (mean 121 ng/ml), respectively. Cord blood was sampled for zolpidem, with a result of 41 ng/ml. Despite the presence of zolpidem in the cord blood sample, the neonate was active and alert after normal delivery. No withdrawal symptoms were noted, and the mother and neonate were discharged home after 48-hour observation. This case report indicates that zolpidem crosses the human placenta, as was exemplified with cord blood sampling. The drug should therefore be used during pregnancy only if clearly necessary.

Askew, J. P. (2007), Zolpidem Addiction in a Pregnant Woman with a History of Second-Trimester Bleeding. Pharmacotherapy, 27: 306–308. doi: 10.1592/phco.27.2.306.

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Department of Pharmacy, New Hanover Health Network, Wilmington, North Carolina.

Volume 27, Issue 2, pages 306–308, February 2007 Additional Information.

2007 Pharmacotherapy Publications Inc. Issue.

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9/17/2014
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