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Zolpidem mechanism of action





DrugBank Zolpidem (DB00425)

6/4/2014
05:49 | Author: Brandon Powell

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DrugBank Zolpidem (DB00425)

Zolpidem is a prescription short-acting nonbenzodiazepine hypnotic that Mechanism of action, Zolpidem modulates the alpha-subunit, known.

Zolpidem is converted to inactive metabolites in the liver.

Zolpidem is a prescription short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid ( GABA ), an inhibitory neurotransmitter, by binding to benzodiazepine receptors which are located on the gamma-aminobutyric acid receptors. Zolpidem is used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). It is classified as an imidazopyridine. As an anticonvulsant and muscle relaxant, the beneficial effects start to emerge at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Recently, zolpidem has been cited in various medical reports mainly in the United Kingdom as waking persistent vegetative state ( PVS ) patients, and dramatically improving the conditions of people with brain injuries.

Markus Sauter, “Process for preparing zolpidem.” U.S. Patent US, issued December 05, 2002. Kind: protein Organism: Human Pharmacological action: yes Actions: potentiator Kind: protein Organism: Human Pharmacological action: unknown Actions: agonist Kind: protein Organism: Human Pharmacological action: unknown Actions: agonist Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate Kind: protein Organism: Human Pharmacological action: unknown Actions: substrate.

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Mechanism of action of the hypnotic zolpidem in vivo

4/3/2014
07:58 | Author: David Perry

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Mechanism of action of the hypnotic zolpidem in vivo

Zolpidem is a widely used hypnotic agent acting at the GABAA receptor benzodiazepine site. On recombinant receptors, zolpidem displays a high affinity to.

Diazepam and zolpidem were suspended in a 0.3% Tween 80/saline solution. Pentylenetetrazole (PTZ, Sigma, Buchs, Switzerland) was dissolved in saline. All drugs were administered in a volume of 5 ml kg−1.

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We thank Daniel Blaser, Humberto Pochetti and Guido Schmid for animal care. This work was supported by a grant from the Swiss National Science Foundation.

Under vehicle treatment, wild type and α 1 (H101R) mice displayed a similar level of motor activity.

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Zolpidem Tartrate Drug Information, Professional

12/12/2014
01:13 | Author: Nick Jenkins

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Zolpidem Tartrate Drug Information, Professional

Mechanism of action/Effect: Zolpidem is a potent {10} agonist {10} with high intrinsic activity {10} at the omega (ω) 1 subtype {01} {02} {03} {28}.

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Data sources include Micromedex (updated Sep 26th, 2014), Cerner Multum (updated Oct 16th, 2014), Wolters Kluwer (updated Oct 9th, 2014) and others. To view content sources and attributions, refer to our editorial policy.

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Ambien CR - FDA prescribing information, side effects and uses

10/11/2014
01:36 | Author: Emma Coleman

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Ambien CR - FDA prescribing information, side effects and uses

Ambien CR (zolpidem tartrate extended-release tablets) is indicated for the treatment of insomnia characterized by difficulties with sleep.. Mechanism of Action.

The frequencies presented, therefore, represent the proportions of the 3,660 individuals exposed to zolpidem, at all doses, who experienced an event of the type cited on at least one occasion while receiving zolpidem. All reported treatment-emergent adverse events are included, except those already listed in the table above of adverse events in placebo-controlled studies, those coding terms that are so general as to be uninformative, and those events where a drug cause was remote.

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The Pharmacology and Mechanism of Action of Zolpidem

8/10/2014
03:05 | Author: Kayla Henderson

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The Pharmacology and Mechanism of Action of Zolpidem

The Pharmacology and Mechanism of Action of Zolpidem. David J. Sanger and Henri Depoortere. Synthélabo Recherche, Bagneux, France. Key Words:.

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