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Zolpidem Metabolites in Urine





A simple and rapid method for the identification of zolpidem

12/17/2014
03:13 | Author: Nick Jenkins

Ambien Drug Test Detection
A simple and rapid method for the identification of zolpidem

Detection of the drug in urine is extremely difficult because of its extensive metabolism. A method is presented for the detection and quantitation of zolpidem.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

Zolpidem is a non-benzodiazepine hypnotic that has been implicated in both drug-facilitated sexual assault and drink spiking. Detection of the drug in urine is extremely difficult because of its extensive metabolism. A method is presented for the detection and quantitation of zolpidem carboxylic acid (ZCA), the major urinary metabolite of zolpidem. The metabolite was extracted from urine at pH 4.5-5.0 with chloroform/isopropanol alkylated with ethyl iodide and identified by gas chromatography-mass spectrometry in the selected ion-monitoring mode. Following a single ingestion of 10 mg zopidem, ZCA is detected for up to 72 h. The limit of detection is 2 ng/mL, with an overall recovery of 80%. Using this procedure, zolpidem was identified in two cases of alleged drug-facilitated sexual assault.

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Direct determination of zolpidem and its main metabolites in urine

10/16/2014
01:34 | Author: Lauren Ross

Ambien Drug Test Detection
Direct determination of zolpidem and its main metabolites in urine

Zolpidem is a new sleep inducer belonging to the imidazopyridine class. We wish to report a method for the determination of zolpidem and its main metabolites.

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Volume 675, Issue 1, 12 January 1996, Pages 131–137 No articles found.

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