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Zolpidem pharmacokinetics





Clinical pharmacokinetics and pharmacodynamics of zolpidem

11/24/2014
09:28 | Author: Emma Coleman

Zolpidem dosing
Clinical pharmacokinetics and pharmacodynamics of zolpidem

Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications. Salvà P, Costa J. Zolpidem is an imidazopyridine which differs in.

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Zolpidem is an imidazopyridine which differs in structure from the benzodiazepines and zopiclone. It is a strong sedative with only minor anxiolytic, myorelaxant and anticonvulsant properties, and has been shown to be effective in inducing and maintaining sleep in adults. The available evidence suggests that zolpidem produces no rebound or withdrawal effects, and patients have experienced good daytime alertness. Zolpidem 10mg in non-elderly and a reduced dose of 5mg in elderly individuals are clinically effective.

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Pharmacokinetic properties of zolpidem in elderly and young adults

11/23/2014
07:04 | Author: Lauren Ross

Drugs for insomnia treatment
Pharmacokinetic properties of zolpidem in elderly and young adults

The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers.

The study protocol was reviewed by the local Institutional Review Board and informed consent was obtained from all subjects. Forty Caucasian volunteers participated in the study. They were divided into two groups of those aged 21–42 years ( n = 24), and those aged 66–85 years ( n = 16) ( Table 1 ). All subjects were healthy, ambulatory and medically stable. Among the elderly, two subjects were on digoxin, one on aspirin, and one each on perindopril and phenprocoumon. None of these drugs is known to induce or inhibit CYP3A4.

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Pharmacokinetics - Intermezzo (zolpidem tartrate) sublingual tablet

9/22/2014
05:56 | Author: Emma Coleman

Zolpidem tartrate wiki
Pharmacokinetics - Intermezzo (zolpidem tartrate) sublingual tablet

Studies showed Intermezzo achieved peak mean plasma levels of zolpidem in about The clinical significance of pharmacokinetic data is unknown; Food.

The most commonly observed adverse reactions (> 1%) were headache (Intermezzo 3%, placebo 1%), nausea (1% for both patient groups), and fatigue (Intermezzo 1%, placebo 0%).

The risk of next-day driving impairment (and psychomotor impairment) is increased if Intermezzo is taken with less than 4 hours of bedtime remaining; if higher than recommended dose is taken; if co-administered with other CNS depressants; or co-administered with other drugs that increase the blood levels of zolpidem.

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Chapter 5 Pharmacokinetics, pharmacodynamics, and the

7/21/2014
03:28 | Author: David Perry

Drugs for insomnia treatment
Chapter 5 Pharmacokinetics, pharmacodynamics, and the

Pharmacokinetics, pharmacodynamics, and the pharmacokinetic/pharmaco- dynamic relationship of zolpidem in healthy subjects. (Adapted version accepted for.

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Gender differences in pharmacokinetics and pharmacodynamics of

5/20/2014
01:20 | Author: David Perry

Zolpidem tartrate wiki
Gender differences in pharmacokinetics and pharmacodynamics of

Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration. David J. Greenblatt MD.

* Corresponding author: David J. Greenblatt, MD, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston MA 02111, USA.

Greenblatt, D. J., Harmatz, J. S., Singh, N. N., Steinberg, F., Roth, T., Moline, M. L., Harris, S. C. and Kapil, R. P. (2014), Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration. Journal of Clinical Pharma, 54: 282–290.

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