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Zolpidem solubility





Zolpidem 98 (HPLC), solid Sigma-Aldrich

10/19/2014
10:38 | Author: Emma Coleman

Zolpidem solubility
Zolpidem 98 (HPLC), solid Sigma-Aldrich

Sigma-Aldrich offers Sigma-Z103, Zolpidem for your research needs. Find product solubility, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble0.3 mg/mL.

Lower doses of sublingual Zolpidem are more effective than oral Zolpidem to anticipate sleep onset in healthy volunteers. Valente KD, Hasan R, Tavares SM, et al. Sleep Med. 14(1), 20-3, (2013).

Efficacy of eight months of nightly zolpidem: a prospective placebo-controlled study. Randall S, Roehrs TA, and Roth T Sleep 35(11), 1551-7, (2012).

Zolpidem is independently associated with increased risk of inpatient falls.

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Injecting - can one inject ambien (zolpidem)? - Drugs Forum

12/18/2014
08:16 | Author: Lauren Ross

Side effects of insomnia medication
Injecting - can one inject ambien (zolpidem)? - Drugs Forum

Swims read at different places online that i.v'ing ambien(zolpidem) can a few questions for safety sake = is ambien(zolpidem) water soluble.

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Patent EP1163241A1 - Zolpidem salts - Google Patents

10/17/2014
06:26 | Author: Emma Coleman

Zolpidem solubility
Patent EP1163241A1 - Zolpidem salts - Google Patents

1999:1280, states that zolpidem tartrate is characterized as a white or almost white crystalline powder, hygroscopic, slightly soluble in water.

One way to obtain such a salt is by having a molar ratio of protonated zolpidem moiety to anion in the range of about 0.9-1.35:1, more preferably about 1:1. Such salts represent another aspect of the present invention. The salts according to the present invention can be made from pharmaceutically acceptable acid addition salts such as hydrochloride, hydrobromide, maleate, fumarate, tartrate, sulfate and sulfonates.

The invention also relates to the use of the physically stable zolpidem salts of the present invention as intermediates in the preparation of another zolpidem salt including the known zolpidem tartrate.

A product that substantially consists of this zolpidem hydrogentartrate crystalline salt can be prepared in reproducible manner and in industrial scale as will be shown herein below.

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