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Zolpidem vegetative state





Zolpidem arousing effect in persistent vegetative state patients

9/13/2014
02:19 | Author: Brandon Powell

Side effects of ambien 10 mg
Zolpidem arousing effect in persistent vegetative state patients

Zolpidem arousing effect in persistent vegetative state patients: autonomic, EEG and behavioral assessment. Machado C, Estévez M, Rodríguez R, Pérez-Nellar.

We studied a group of 8 PVS patients and other 8 healthy control subjects, matched by age and gender. The patients and controls received drug or placebo in two experimental sessions, separated by 10-14 days. The first 30 minutes of the session were considered the basal record, and then Zolpidem was administered. All participants were evaluated clinically, by EEG, and by HRV during the basal record, and for 90 minutes after drug intake.

To study the Zolpidem arousing effect in persistent vegetative state (PVS) patients combining clinical evaluation, autonomic assessment by heart rate variability (HRV), and EEG records.

We demonstrated time-related arousing signs after Zolpidem intake. We discussed possible mechanisms to explain these patho-physiological findings regarding EEG cortical activation and an autonomic vagolytic drug effect. As this autonomic imbalance might induce cardiocirculatory complications, which we didn't find in any of our patients, we suggest developing future trials under control of physiological indices by bedside monitoring. However, considering that this arousing Zolpidem effect might be certainly related to brain function improvement, it should be particularly considered for the development of new neuro-rehabilitation programs in PVS cases. According to the literature review, we claim that this is the first report about the vagolitic effect of Zolpidem in PVS cases.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

We found in all patients, time-related arousing signs after Zolpidem intake: behavioral (yawns and hiccups), activation of EEG cortical activity, and a vagolytic chronotropic effect without a significant increment of the vasomotor sympathetic tone.

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Drug induced arousal from the permanent vegetative state

7/12/2014
04:02 | Author: David Perry

Side effects of ambien 10 mg
Drug induced arousal from the permanent vegetative state

Drug induced arousal from the permanent vegetative state. Clauss R, Nel W. BACKGROUND: Zolpidem is an omega 1 specific indirect GABA agonist that is.

Zolpidem appears an effective drug to restore brain function to some patients in the permanent vegetative state.

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Zolpidem is an omega 1 specific indirect GABA agonist that is used for insomnia, but may have efficacy in brain damage. The long term efficacy of zolpidem in the permanent vegetative state is described in three patients.

All patients were aroused transiently every morning after zolpidem. Glasgow Coma Scale scores ranged from 6-9/15 before to 10-15/15 after zolpidem. Rancho Los Amigos Cognitive scores ranged from I-II before to V-VII afterward. Drug efficacy did not decrease and there were no long term side effects after 3-6 years daily use.

Two motor vehicle accident patients and one near drowning patient, all of them in the permanent vegetative state for at least three years, were rated according to the Glasgow Coma and Rancho Los Amigos scale before and after zolpidem application. Long term response to daily application of this drug was monitored for 3-6 years.

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Waking the unconscious the latest science on awakenings TIME.com

5/11/2014
06:03 | Author: Nick Jenkins

Side effects of ambien 10 mg
Waking the unconscious the latest science on awakenings TIME.com

In 2002, a doctor prescribed the common sleep drug zolpidem People in a vegetative state have wakeful periods when their eyes are open.

Although the brain damage and its cause were different in each patient, Schiff and his associates discovered that all three had the same unusual pattern of brain activity when they were monitored by electroencephalogram (EEG): a spike of activity, at a low frequency (7.5 Hz) that was tightly synchronized across both halves of the brain and most prominent over the front of the brain. This abnormal pattern—akin to a motor idling rather than engaging its gears—disappeared when the patients were given Ambien.

How these interventions work and why they help some and not others is a critical question for researchers, says Dr.

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BBC NEWS Health Pill 39reverses39 vegetative state

3/10/2014
08:16 | Author: Emma Coleman

Side effects of ambien 10 mg
BBC NEWS Health Pill 39reverses39 vegetative state

Zolpidem is usually used to treat insomnia. A person in a vegetative state will appear to be awake and may have their eyes open, but will.

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PVS - Zolpidem after brain injury - Google Sites

1/9/2014
10:55 | Author: Kayla Henderson

Side effects of ambien 10 mg
PVS - Zolpidem after brain injury - Google Sites

Zolpidem after traumatic brain injury, stroke, anoxic brain damage, Vegetative State, Minimally Conscious state, Locked in Syndrome, Neurological impairment.

For further information on neurodormancy, please click on - Brain dormancy theory - in the main menu. References.

-No evidence of awareness of self or environment; no interaction with others.

-Bowel and bladder incontinence-Variably preserved cranial nerve and spinal reflexes.

-No evidence of sustained, reproducible, purposeful or voluntary behavioral responses to visual, auditory, tactile or noxious stimuli.

-Return of sleep-wake cycles, arousal, even smiling, frowning, yawning.

-Sufficient hypothalamic and brainstem autonomic functions to survive if given medical or nursing care.

-No evidence of language comprehension or expression.

Zolpidem’s proposed mode of action is the modulation of ‘abnormal’ GABA receptors that are responsible for Brain dormancy in the Vegetative State, neurodormancy (4).

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