Zolpidem used in this manner (Crushed, Diluted and Injected) is ill advised by all medical authorities, Doctors are writing prescriptions for this medication on the basis that the Prescribed Zolpidem be taken orally and on a short term basis.
Source: http://www.wikinvest.com/stock/Sanofi-Aventis_SA_(SNY)/Filing/6-K/2009/F3487616. This excerpt taken from the SNY 6-K filed Jul 29, 2009.
Remove - After repeated requests, no information (and even the "1500 articles" misleading information) to support the merits of including this spam. 188.8.131.52 ( talk ) 16:08, 7 February 2014 (UTC).
I still love you Fae. ----The Good Doctor —Preceding unsigned comment added by 184.108.40.206 ( talk ) 08:00, 12 March 2011 (UTC).
I agree - what is with the love of pics for this drug, isn't the typical example (both name-brand and generic) the long skinny shape? I've looked into published books that seem to favor the long skinny shape - aren't endless pics of rounded tablets pointless? — Preceding unsigned comment added by 220.127.116.11 ( talk ) 07:00, 9 April 2014 (UTC).
That slang for being high on ambien is nonsense. "Lost"? That is probably just what one group of high school kids who are stealing it from their mom call it. Unlike like getting "dusted" or "wet" on pcp, or "tweaked" on meth, there is not really any widely accepted slang for the ambien high. Also, I moved the note about ambien being used by stimulant abusers for the comedown from "Off-label use" to this section--that is recreational use, not off-label. Off label means what doctors script it for despite it not being FDA approved for. —Preceding unsigned comment added by 18.104.22.168 ( talk ) 03:28, 12 March 2011 (UTC).
What is known is that crushing up a pill and diluting it to be used in IV, IM or SC injections of Zolpidem is ill advised by the medical community - no doctor would write a script for an oral tablet if they knew it was being used in this manner. 22.214.171.124 ( talk ) 08:09, 24 October 2011 (UTC).
" no thank you, if you're interested you're welcome to find the previous discussions but it's not worth my time ": Then please don't make claims that you're not willing to back up. I could claim that the moon is made of cheese and add that to Moon, but that doesn't make it true. We are left with the conclusion that your claims have no basis in reality. 126.96.36.199 ( talk ) 15:01, 6 February 2014 (UTC).
I don't know where this oft-repeated mention of a 2-3 hour half-life came from, but the US NIH shows a time profile of zolpidem's plasma concentration which pegs the half-life at 4 hours for male subjects, and an updated version of the product information ( http://products.sanofi.us/ambien_cr/ambienCR.html ) states that female plasma concentration is "up to 3 times higher" than males from 6-12 hours after dosage, which puts the upper bound of the half-life around 8 hours. I will edit the article accordingly. 188.8.131.52 ( talk ) 15:58, 26 July 2014 (UTC).
I think this wiki needs a rewrite from an expert.
" Ambien (zolpidem tartrate) Product Litigation In March 2006, a lawsuit seeking class action treatment was filed with the U.S. District Court for the Southern District of New York naming sanofi-aventis’ U.S. subsidiary Sanofi-Synthélabo Inc. as defendant and seeking unspecified damages for harm allegedly caused by claimed product side effects. In May 2007, the U.S. District Court for the Southern District of New York entered an order dismissing the class action complaint in its entirety without prejudice. ".
The medical section is like 2.5 times shorter then recreational section. That's just not right. — Preceding unsigned comment added by 184.108.40.206 ( talk ) 15:31, 27 October 2012 (UTC).
Ggkla990 ( talk ) 19:24, 16 June 2011 (UTC).
Regarding your edit ( 220.127.116.11 ( talk )).
"After over a year of investigation and reviewing about 1,000 forms and other data from people nationwide, it was determined that there were too many different factual differences between potential claimants that would prevent a class from being certified by the court. The law requires common injuries and damages between everyone. In this case, everyone had a difference, whether it was their being on other medications or how they took Ambien; it was different enough to determine a class action was not best. Our offices always maintained from the start of this action that our goal was twofold: (1) to make people aware that they could suffer adverse reactions from Ambien that they did not know about and (2)to get stronger warnings about this drug. I accomplished that when I put this issue in the media and on March 14, 2007 the FDA directed the Ambien manufacturer to provide the very warnings this lawsuit demanded. No other office nationwide would at least take that responsibility. We did, and we got a result, and we did not receive any compensation other than accomplishing what we promised." http://www.appellate-brief.com/knowledge/class-actions/ambien.
Remain - The link to erowid should remain because it contains valuable information about recreational use. There are no advertisements or sales pitches on the site. Testem ( talk ) 11:40, 7 February 2014 (UTC).
there is not a3. only a2 link. —Preceding unsigned comment added by Ericg33 ( talk • contribs ) 01:21, 22 January 2010 (UTC).
From my own experience, Zolpidem plus alcohol hugely enhances the possibility of "blackouts" - periods when you appear to be functional, but have absoluy no memory of it afterward. This effect is well known "on the street" and in blogs, but I haven't seen a peer-reviewed study that confirms it, so I didn't amend the main article. Believe me, it's a major problem for the unwary, and, in the USA, the medication comes with a very clear warning of this side effect. 18.104.22.168 ( talk ) 06:26, 8 February 2013 (UTC).
Also, it says the half like is 2-3 hours. My doctor looked it up and it has a half life of 10 hours.
I notice that Excretion is 56% renal; 34% fecal - which only adds up to 90%. Does the other 10% need to be accounted for, or is there a typo? — Preceding unsigned comment added by 22.214.171.124 ( talk ) 23:37, 5 July 2011 (UTC).
-No, from everything I can find it is a non benzodiazepine. Your doctor appears to be wrong. Ayzmo ( talk ) 17:38, 20 September 2011 (UTC).
Is there any updated information on the class-action lawsuit related to Ambien? This article says that the lawsuit started in 2006. After this many years, there should be some resolution by now (or at least some activity we could update). ChemNerd ( talk ) 16:48, 16 January 2011 (UTC).
In this edit an image was deleted. It was an official government photo, freely licensed. Yes, it has a typo in it, but that is not a valid reason for deletion, given that the correct name for the drug is omnipresent in this article. Yes, it's small, but that's not a good reason for deletion either. If a better picture is desired, create it first, before deleting existing ones. -- Lexein ( talk ) 03:41, 15 September 2012 (UTC).
It would be a nice addition to have Countries Available, or Name of Drug in Country X, or something like that. I have seen this on some of the pharmaceutical entries, but not all. It's nice to know before traveling that a country doesn't even have your med on its formulary, for instance, in addition to the consistency factor. — Preceding unsigned comment added by 126.96.36.199 ( talk ) 01:33, 16 March 2012 (UTC).
An IP is challenging the Erowid link we currently have in the external links section on the ground that it "adds nothing" to the article. Being that the Erowid vault contains information such extra details on its legal status, first hand experiences, and pill images, I can only assume the IP editor hasn't thoroughly read the page. It's worth mentioning that Erowid is linked over 1500 times on various psychoactive drug pages and has been discussed numerous times in the past with a general consensus that it's a worthwhile compendium of information, so I also assume the editor isn't familiar with Erowid's history. The IP has made 3 reversions and I have made two, so I'd appreciate if someone else got involved. N o f o rmation Talk 03:33, 6 February 2014 (UTC).
The long term affects are not known from long term use of Zolpidem because it's not a drug that is issued on a long term basis, it's a drug that is trialled for a few weeks in most 1st world countrys. The long term effects of Zolpidem being crushed and injected into the patient intravenously or intramuscularly or subcutaneously are not known, this only strengthens the stringency in Doctors unwillingness to prescribe Zolpidem.
I think this one needs a rewrite from an expert.
I clearly substantiated the reasons for the link's inclusion in the article in my edit reversion, and User:Noformation has here. The link contains substantial information about recreational use of zolpidem. You have failed to provide any reason that it might be spam. For starters, erowid is not a vendor site. I am sure that User:Exercisephys will also contribute to a constructive consensus if you are not happy being disagreed with 2:1. Testem ( talk ) 09:42, 7 February 2014 (UTC).
I use this drug and in the info from the pharmacy it states that it belongs to the group of benzodiazepines. The article says it's a non benzodiazepine. This s a critical difference.
@ Testem : @ Meteor sandwich yum : @ Noformation : I responded below. I would like to also point out that the IP is likely from Herndon, VA, a suburb in which many DEA agents and other federal officers live. We've had problems with biased edits by such IPs on the Drug Enforcement Administration article. Exercisephys ( talk ) 16:17, 7 February 2014 (UTC).
I'm not from a Legal background but I assume that means the lawsuit didn't happen? Perhaps someone who understand you append that section? Also found this:
It's still in a very experimental stage and as I said earlier the adverse affects from this are unknown both short and long term.
See the article on Wikipedia here about Baclofen and it's less-reported but readily available in the US as a supplement steroisomer, Phenibut. This is powerful GABA-b agonist and should be added to the list at the bottom of the page. — Preceding unsigned comment added by Hilslamer ( talk • contribs ) 18:45, 19 April 2012 (UTC).
Ok, maybe someone wants to be able to identify the pills, but do we really need so many copies?-- 188.8.131.52 ( talk ) 20:30, 9 May 2010 (UTC).
I was researching this, and found the following:
It's also important to remember that not a single pharmaceutical company that manufactures Zolpidem recommends this drug to be taken in this manner, in fact they all advise against long term use and in Australia Zolpidem is one of the only pharmaceutical prescription based medicine that has been given a "Black Box Warning" which is very similar to the FDA warning.
I've retitled this section to "recreational and illegal use" due to the note about its use in sexual assault, which really shouldn't be included in "recreational use". - 184.108.40.206 ( talk ) 22:18, 12 January 2011 (UTC).
Remain - Upon further thought, I think it should remain. Erowid is a valuable and trusted resource with a lot of unique, reliable information Exercisephys ( talk ) 02:44, 8 February 2014 (UTC).
I apologize, I added this comment to an existing post. I just signed up and misunderstood.
I am a physician and object to the phrasing "recreational" use. When prescription drugs are used in a way other than intended, or when illegal drugs are used at all, it is not "recreation" (which sounds innocent or playful) but a crime. I never use the term "recreational" drug use and I suggest that the term has no role in the context of a supposedly scientific article. Robert Fields, M.D. — Preceding unsigned comment added by 220.127.116.11 ( talk ) 16:12, 4 July 2012 (UTC).
In regards to experimental use Doctors cannot issue the script... simply because in evidence based medicine they have no authority to issue the script, a Doctor is not going to put "Crush with mortar and pestle, dilute, inject" on a prescription, the liability would be terrible for the doctor, it's extremely risky and no Doctor in his/her right frame of mind would issue the script with the knowledge that the Zolpidem is not taken as directed and instead "abused".
The text states "Large-scale studies are currently being done to see whether it has the same universal effect on all or most patients in a minimally conscious state " and references (ref 27) Dziedzic J, Neurology Reviews, 15(9),September 2007. However, all this reference states regarding zolpidem is that "other potential therapeutic options for patients in a minimally conscious state, such as pharmacologic therapies like Ambien (zolpidem tartrate) and Paxil (paroxetine), or a combination of a pharmacologic agent and deep brain stimulation, remain to be investigated as well ". Indeed, the reference actually describes a study of the efficacy of deep brain stimulation and can not be cited as documentation for the statement in the entry. I think the line should be marked needs citation, unless a more appropriate reference can be provided. -- PloniAlmoni ( talk ) 18:29, 17 August 2010 (UTC).
No, the page is right. The drug's effects barely last for 2-3 hours. It's definiy not a benzo, but it's closely related to them. 18.104.22.168 ( talk ) 12:02, 19 February 2012 (UTC).
"containing the α2 - and α3 - GABAA receptor subunits, and".
Ggkla990 ( talk ) 19:14, 16 June 2011 (UTC).
I hid the compley irrelevant and unnecessary comment that alcohol is the most common date rape drug. Imaslee pviking ( talk ) 02:51, 11 January 2013 (UTC).
I'm not sure about any other errors, but these are important enough for this wiki to be unreliable, especially the non benzodiazepine error. So ask your doctor about this drug instead of relying on this wiki.
Regarding errors in this wiki, I use this drug and noticed two things. I the info I got from the pharmacy it says that this drug belongs to the group of benzodiazepine, so it's not a non benzodiazepine. Also, my doctor told me it has a half life of 10 hours, which is considerably longer than the 2-3 hours mentioned in the article.
Why are The Netherlands mentioned as one of the biggest Zolpidem-using countries? What's the relevancy? — Preceding unsigned comment added by 22.214.171.124 ( talk ) 07:47, 29 February 2012 (UTC).
I Apologize. In attempting to remove the unsupported line about ambien slang, I messed up the citation for the previous line. I do not know how to fix this. Or it says "Cite error" where I deleted the line about being "lost" on ambien. —Preceding unsigned comment added by 126.96.36.199 ( talk ) 03:39, 12 March 2011 (UTC).
With the comment "this doesn't belong here", this text was removed: "In the Australian media Stilnox was referred to as the drug used to produce surprising, yet transient, recovery in Sam Goddard, a patient who had suffered brain injury. After a 15 mg dose, Goddard is able to speak for up to an hour, while at other times he is unable to do so." Why doesn't it belong in this article? It's highly relevant and appropriate in my opinion. I vote to have this re-added. Mgwalker ( talk ) 04:58, 14 July 2011 (UTC).
In looking at the Intermezzo (zolpidem titrate) page, there is a heading at the top that suggests the page should be merged with Zolpidem since 12/2011. Is this heading outdated, or should it be addressed? Perhaps a note at the top saying something along the lines of "Click Zolpidem if you are looking for information on the general medication category. Intermezzo is a name brand manufactured version of Zolpidem that is both sublingual and at a lower dosage than previously released versions of zolpidem." — Preceding unsigned comment added by Arope28 ( talk • contribs ) 01:03, 12 February 2013 (UTC).